鐜涘反娲涙矙闊︾墖浜轰綋鐢熺墿绛夋晥鎬х爺绌跺垎鏋
鍙戝竷鏃堕棿锛
2023-06-09
鏉ユ簮锛
涓€銆?/strong>鑳屾櫙
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鏈枃灏嗙粨鍚堢浉鍏虫寚瀵煎師鍒欏拰鏂囩尞鐮旂┒锛岃缁嗛槓杩扮帥宸存礇娌欓煢浜轰綋鐢熺墿绛夋晥鎬ц瘯楠岀殑涓€鑸€冭檻锛屽鏈搧浜轰綋鐢熺墿绛夋晥鎬х爺绌剁殑鑻ュ共鍏抽敭璁捐杩涜鎺㈣锛屾棬鍦ㄤ负姝ょ被浜у搧鐨勪豢鍒跺拰娉ㄥ唽鐢虫姤鎻愪緵鍙傝€冦€侟/span>
浜屻€?/strong>鑽墿绠€浠婞/strong>
閫氱敤鍚嶇О锛欬/strong>鐜涘反娲涙矙闊︾墖
鍟嗗搧鍚嶇О锛欬/strong>Baloxavir Marboxil Tablets
鑻辨枃鍚嶇О锛欬/strong>Aspirin Enteric-coated Tablets
鍖栧缁撴瀯寮忥細
瑙勬牸锛欬/strong>80mg銆?0mg
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涓夈€?/strong>澶勬柟宸ヨ壓鍜岀悊鍖栨€ц川
1銆佸鏂圭粍鎴愪笌鐞嗗寲鎬ц川
2銆佹憾鍑烘儏鍐袋sup>[6]
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鍥? 鐜涘反娲涙矙闊︾墖鏈姞琛ㄩ潰娲绘€у墏鐨勬憾鍑烘洸绾军/span>
鍥? 鐜涘反娲涙矙闊︾墖娣诲姞0.07% CTAB鍚庣殑婧跺嚭鏇茬嚎
浠庢憾鍑烘洸绾垮彲鐭ワ紝鍦ㄤ笉鍔犺〃闈㈡椿鎬у墏鏃讹紝涓嶅悓鐨刾H鏉′欢涓嬬殑婧跺嚭搴﹀彉鍖栦笉鏄庢樉锛屼笖婧跺嚭鑰冨療缁撴潫鏃舵憾鍑洪噺鍧囨湭杈惧埌85%銆備絾鍦ㄤ娇鐢ㄤ簡琛ㄩ潰娲绘€у墏鍚庯紝婧跺嚭鐗瑰緛褰㈡垚杈冨ぇ宸紓锛屽叾婧惰В搴﹀嚑涔庣炕浜嗕竴鍊嶏紝澧炴憾鏁堟灉闈炲父鏄庢樉銆侟/span>
鍥涖€?/strong>鐢熺墿绛夋晥鎬ц瘎浠饵/strong>
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1銆佺爺绌剁被鍨婞/strong>
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2銆佽鏍烽噰闆嗗拰娓呮礂鏈烖/strong>
鏍规嵁鍘熺爺璇存槑涔?sup>[8]鍙煡锛岀┖鑵瑰崟娆″彛鏈?0 mg鏈搧鍚庯紝宸存礇娌欓煢鐨勮娴嗘祿搴﹁揪宄版椂闂达紙Tmax锛夌害涓?灏忔椂锛岃繘椋熶笉褰卞搷宸存礇娌欓煢鐨勮揪宄版椂闂淬€傞珮鍔犵储鎮ｈ€呬腑宸存礇娌欓煢鐨勮〃瑙傜粓鏈秷闄ゅ崐琛版湡锛坱1/2锛変负79.1灏忔椂锛屾棩鏈彈璇曡€呬腑涓?3.9灏忔椂銆傚師鐮旇祫鏂欎互鍙婃枃鐚爺绌朵腑鑽唬鍔ㄥ姏瀛﹀弬鏁板強鑽椂鏇茬嚎濡備笅锛欬/span>
鍥? 鍗曟鍙ｆ湇40 mg鐜涘反娲涙矙闊﹀悗鐨勮鑽祿搴︽洸绾垮浘
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[4] 榛勫厜浜?浣曟枃濞?璧垫檽濞?绛? 鏂板瀷Cap渚濊禆鎬у唴鍒囬叾鎶戝埗鍓傜帥宸存礇娌欓煢娌荤枟娴佹劅鐨勪复搴婄爺绌惰繘灞昜J]. 涓浗鏂拌嵂涓庝复搴婃潅蹇?2022,41(11):641-645.
[5] 鏆存定14717%锛佹瘮甯冩礇鑺繕闅炬姠锛?ldquo;绁炶嵂”涓轰綍绐佺劧涓€澶滃ぇ鐏紵鍓嶈█浜т笟鐮旂┒
[6] Clinical Pharmacology Biopharmaceutics Review(s), Xofluza
[7] .U.S. Food and Drug Administration. Draft Guidance on Baloxavir Marboxil. 2023.
[8] 閫熺杈惧師鐮旇繘鍙ｈ鏄庝功.
[9] 鍘熺爺Xofluza鏃ユ湰IF鏂囦欢.
[10] Gouda Amira S,Abdel-Megied Ahmed M,Rezk Mamdouh R et al. LC-MS/MS-based metabolite quantitation of the antiviral prodrug baloxavir marboxil, a new therapy for acute uncomplicated influenza, in human plasma: Application to a human pharmacokinetic study.[J] .J Pharm Biomed Anal, 2023, 223: 115165..
[11] 銆婁互鑽姩瀛﹀弬鏁颁负缁堢偣璇勪环鎸囨爣鐨勫寲瀛﹁嵂鐗╀豢鍒惰嵂浜轰綋鐢熺墿绛夋晥鎬х爺绌舵妧鏈寚瀵煎師鍒欍€?
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